Is asthma a multifactorial disease?
Is asthma a multifactorial disease?
Rather, asthma is a polygenic, multifactorial disorder, which means that many factors contribute to its development. These factors are both genetic and environmental; accordingly, the combined action of several genes interacting with one another and with environmental factors causes the condition (1).
What genetic mutation causes asthma?
“In this study we found that a mutation in the YKL-40 gene is associated with YKL-40 levels in the blood, a diagnosis of asthma, and impaired lung function. Ultimately, blocking the effects of YKL-40 may prove to be a novel and effective way to treat asthma.”
How is asthma a multifactorial genetic disease?
[1] [2] Asthma is considered a complex or multifactorial condition that is likely due to a combination of multiple genetic, environmental, and lifestyle factors. Many people with asthma have a personal or family history of allergies, such as hay fever or eczema.
What makes asthma a complex and rare disease?
Asthma is considered a complex or multifactorial condition that is likely due to a combination of multiple genetic, environmental, and lifestyle factors. Many people with asthma have a personal or family history of allergies, such as hay fever or eczema.
Can a person with asthma have a cough?
CVA is a subtype of asthma that usually presents solely with cough without any other symptoms such as dyspnea or wheezing [8]. In cough-predominant asthma cough is the most predominant symptom but other symptoms are also present such as dyspnea and/or wheeze [19-21]. These symptoms can be elicited on careful clinical history and examination.
How is mucus secretion related to chronic asthma?
Mucus hyper-secretion in asthma may be potentially related with steeper decline of pulmonary function [27] and fatal disease [28]. Measurement of secreted mucin in sputum has been reported in asthma [29], but not in chronic cough, which may involve goblet cell hyperplasia of bronchial epithelium with variable sputum production [30,31].