What kind of genes does IRF7 encode?
What kind of genes does IRF7 encode?
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes.
What is the role of IRF7 in the body?
IRF7 is required for the production and amplification of the antiviral type I (IFN-α/β) and III (IFN-λ) IFNs. The patient’s fibroblasts displayed impaired IFN-β and IFN-λ1 production in response to various stimuli, including IAV.
How is the IRF7 pathway used to treat breast cancer?
The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.
How is IFN production dependent on IRF-7?
Furthermore, robust induction of IFN production by activation of the TLR9 subfamily in plasmacytoid dendritic cells is entirely dependent on IRF-7, and this MyD88-IRF-7 pathway governs the induction of CD8+ T-cell responses.
How does IRF7 interact with IRF3 and AIP?
IRF7 has been shown to interact with IRF3. Also, IRF7 has been shown to interact with Aryl Hydrocarbon Receptor Interacting Protein (AIP), which is a negative regulator for the antiviral pathway.
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General Mills: A U.S.-based food company. We serve the world by making food people love, providing quality brands in more than 100 countries on six continents. Welcome to Global Site ASK US ABOUT OUR FOODCHANGE COUNTRYWelcome to Global Site