What is rilpivirine?
What is rilpivirine?
Rilpivirine is used along with other medications to treat human immunodeficiency virus type 1 (HIV-1) in certain adults and children 12 years of age and older who weigh at least 77 lb (35 kg) and have not received antiretroviral treatment in the past.
Is rilpivirine generic?
No. There is currently no therapeutically equivalent version of Edurant available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Edurant. These medications may be counterfeit and potentially unsafe.
Who owns rilpivirine?
Rilpivirine was developed by Janssen Sciences Ireland UC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson. Rilpivirine is approved in the US and EU as EDURANT® as a 25mg tablet taken once-a-day and is always taken with a meal.
How do you take rilpivirine?
If your health care provider is prescribing rilpivirine with oral cabotegravir (brand name: Vocabria), take rilpivirine and oral cabotegravir by mouth at approximately the same time each day with a meal.
What is rilpivirine used for?
Rilpivirine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Rilpivirine is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Rilpivirine is not a cure for HIV or AIDS.
When was rilpivirine FDA approved?
Titusville, NJ, May 20, 2011 – The US Food and Drug Administration (FDA) today approved EDURANTTM (rilpivirine) tablets for use in combination with other antiretroviral agents (ARVs) in the treatment of human immunodeficiency virus type 1 (HIV-1) in adults who have never taken HIV therapy (treatment‑naïve).
What is TDF 3TC?
SYMFI is a three-drug combination of efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, and lamivudine (3TC) and tenofovir disoproxil fumarate (TDF), both nucleo(t)side reverse transcriptase inhibitors and is indicated as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1 …
When should I take rilpivirine?
Rilpivirine is a type of anti-HIV drug called a non-nuke, or NNRTI. Rilpivirine is approved for use only in people who have never used anti-HIV drugs. Common side effects of rilpivirine include headache, nausea and sleep problems.
What is Cabenuva?
Cabenuva contains two active drug ingredients: cabotegravir and rilpivirine. These ingredients are in two separate injections that you’ll receive once per month. This medication comes in two strengths: 400 milligrams (mg) of cabotegravir/600 mg of rilpivirine and 600 mg of cabotegravir/900 mg of rilpivirine.
What kind of medication is rilpivirine used for?
Rilpivirine, sold under the brand names Edurant and Rekambys, is a medication, developed by Tibotec, used for the treatment of HIV/AIDS. It is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs such as efavirenz.
When was rilpivirine approved for use in the United States?
Rilpivirine entered phase III clinical trials in April 2008, and was approved for use in the United States in May 2011 under the brand name Edurant. A fixed-dose drug combining rilpivirine with emtricitabine and tenofovir disoproxil (TDF), was approved by the U.S. Food and Drug Administration in August 2011 under…
Is there a second generation NNRTI for rilpivirine?
Like etravirine, a second-generation NNRTI approved in 2008, rilpivirine is a diarylpyrimidine (DAPY). Rilpivirine in combination with emtricitabine and tenofovir has been shown to have higher rates of virologic failure than Atripla in patients with baseline HIV viral loads greater than 100,000 copies/mm 3 . ^ “TMC278 — A new NNRTI”. Tibotec.
How is rilpivirine metabolized in the liver?
Independently of the mode of application, rilpivirine is almost completely bound to plasma proteins (99.7%), mostly to albumin. It is metabolised mainly by the liver enzyme CYP3A4. Metabolites include several oxidation products, glucuronides, and glucuronides of oxidized metabolites.