Which of the following is an example of phase 2 metabolism?
Which of the following is an example of phase 2 metabolism?
Conjugation. Glucuronidation, the most common phase II reaction, is the only one that occurs in the liver microsomal enzyme system. Glucuronides are secreted in bile and eliminated in urine. Thus, conjugation makes most drugs more soluble and easily excreted by the kidneys.
What organ is Phase 2 metabolism?
The liver
The liver is the primary site for metabolism. Liver contains the necessary enzymes for metabolism of drugs and other xenobiotics. These enzymes induce two metabolism pathways: Phase I (functionalization reactions) and Phase II (biosynthetic reactions) metabolism.
Which enzyme is most important in Phase 2 metabolism?
Glucuronidation. UDP–glucuronosyltransferases (UGTs) belong among the key enzymes of metabolism of various exogenous as well as endogenous compounds.
Is there second pass metabolism?
However, significant hepatic extraction still occurs because of second pass metabolism, whereby a fraction of venous blood travels through the hepatic portal vein and hepatocytes.
What are the two phases of metabolism quizlet?
How many phases does metabolism have? Explain each. Metabolism has two phases. ANABOLISM: Constructive metabolism.
What are the three phases of metabolism?
The metabolism of xenobiotics is often divided into three phases:- modification, conjugation, and excretion.
What are the similarities between Phase I and Phase II metabolism?
What are the Similarities Between Phase I and Phase II Metabolism? 1 Both phases I and II metabolism involve drug anabolism and catabolism. 2 Also, both phases produce polar molecules. 3 And, they occur in living systems. More
What’s the next step in phonics alliteration games?
The next step, is making up alliterative ‘silly phrases’, such as ‘map mip mop mup’. iv.) The final step is coming up with real alliterative words like ‘terrible tiger’. Lots of the games that I am about to describe address most of these skills, and can be played in an easier form, or a progressively harder form.
Which is the most common modification in Phase 1 metabolism?
The most common modification is hydroxylation. It is catalyzed by cytochrome P-450 dependent mixed function oxidase system. Moreover, the common oxidation reaction during phase I involves the conversion of a C-H bond into a C-OH bond. And, this is important since it converts a prodrug (pharmacologically inactive drug) to an active drug.
What are the two phases of Metab olism?
The oxidations in clude not only the commonly accepted oxida- hydroxylations, dehydroch lorinations, etc… . It ap pears that the metab olism of most for- eign compounds occurs in two phases. The fi rst phase involves oxidations, reductions or formation. In the first phase, biologically activ e compounds may be inacti vated or have