Can simvastatin cause skin problems?
Can simvastatin cause skin problems?
Background: The statin medications for lowering of blood cholesterol can be associated with cutaneous lichenoid reactions but also a variety of other adverse cutaneous eruptions, including Stevens-Johnson syndrome, toxic epidermolytic necrolysis, porphyria cutanea tarda, linear IgA bullous dermatosis, and reaction …
Is 80 mg of simvastatin too much?
[06-08-2011] The U.S. Food and Drug Administration (FDA) is recommending limiting the use of the highest approved dose of the cholesterol-lowering medication, simvastatin (80 mg) because of increased risk of muscle damage.
Can cholesterol medication cause mouth sores?
Whilst many patients with oral ulceration have complex polypharmacy, statins are medications that could potentially be stopped without immediate complications and hence a potential causative link could be established or excluded.
What is a serious adverse reaction to simvastatin?
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Can statins cause sore mouth?
Results showed that a high percentage of oral symptoms included dry mouth, itchiness, bitterness, and cough during statin therapy. There was a marked improvement in their symptoms after temporary interruption of statin treatment.
Can statins cause face rash?
Statins can make your skin more porous, allowing more water to escape, which in turn dries your skin. In some severe cases, statins have been known to cause a dry skin rash and flaky skin that mimics eczema.
Is 80mg statin high?
What is already known? High dose statins (40mg and 80 mg atorvastatin) are important in reducing ASCVD events. However, these high statin doses are associated with increased adverse effects like liver enzyme elevation, new onset diabetes mellitus and myalgia/myopathy which are related to dose.
Is 80 mg of statins a lot?
The maximum dose is 80 mg once a day. The majority of patients are controlled with Atorvastatin 10 mg once a day. A therapeutic response is evident within 2 weeks, and the maximum therapeutic response is usually achieved within 4 weeks.
Do statins cause dry lips?
Studies show that xerostomia is the most common oral side-effect of cardiovascular medication. Statins are common cardiovascular drugs used to treat hypercholesterolemia.
What is the reason for mouth wound?
The most common cause is injury (such as accidentally biting the inside of your cheek). Other causes include aphthous ulceration, certain medications, skin rashes in the mouth, viral, bacterial and fungal infections, chemicals and some medical conditions. An ulcer that won’t heal may be a sign of mouth cancer.
What is simvastatin oral used for?
Simvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver.
Is there a clinical trial for Simvastatin 80 mg?
SEARCH was a seven-year, randomized, double-blind clinical trial comparing the efficacy and safety of simvastatin 80 mg to simvastatin 20 mg, with or without vitamin B12 and folate, in survivors of myocardial infarction.
How does LIPEX simvastatin work for high cholesterol?
LIPEX belongs to a group of medicines known as HMG-CoA reductase inhibitors. It works by reducing the amount of cholesterol made by the liver. In terms of good and bad cholesterol, LIPEX reduces the bad cholesterol and raises the good cholesterol.
How often should you take simvastatin for CHD?
In patients with coronary heart disease (CHD), the initial dose is 40 mg once every evening A dose restriction exists for simvastatin 80 mg due to a higher risk of myopathy and possible rhabdomyolysis, especially within the first 12 months of use.
How is simvastatin used in the United States?
Used together with diet and exercise to reduce the amount of low-density lipoprotein (LDL) cholesterol (“bad cholesterol”) in the blood to decrease the risk of heart attack, stroke, and cardiovascular death. It is estimated that approximately 2.1 million patients in the U.S. were prescribed a product containing 80-mg simvastatin in year 2010.