What is the function of 14-3-3 protein?
What is the function of 14-3-3 protein?
14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and neuroprotection.
What is the function of the 14 3 3 peptide in cell signaling?
Upon interactions with targets, 14-3-3 proteins alter target protein modifications, activity, and cellular localization and therefore regulate five major cellular pathways: cell-cycle and apoptosis, signal transduction, metabolism, and intracellular protein trafficking.
Are prions infectious proteins?
Prions, however, are infectious by their effect on normal versions of the protein. Sterilizing prions, therefore, requires the denaturation of the protein to a state in which the molecule is no longer able to induce the abnormal folding of normal proteins.
What does the 14-3-3 protein stand for?
The 14-3-3 protein is a marker for some prion diseases, such as Creutzfeldt-Jakob disease (CJD), when a number of other neurodegenerative conditions are excluded.
Is the 14-3-3 protein a marker for prion disease?
The 14-3-3 protein is a marker for some prion diseases, such as Creutzfeldt-Jakob disease (CJD), when a number of other neurodegenerative conditions are excluded. Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.
When was the 14-3-3 protein family discovered?
14-3-3 proteins constitute a highly conserved family of eukaryotic proteins (Aitken et al., 1992 ). While proteins of this family were first described in 1967, their biological significance has remained elusive.
Is the 14-3-3 protein a marker for CSF?
14-3-3 Protein, CSF (Prion Disease) – In CSF: Search for the presence of the 14-3-3 protein. The 14-3-3 protein is a marker for some prion diseases, such as Creutzfeldt-Jakob disease (CJD), when a number of other neurodegenerative conditions are excluded.