What is hyperlipidemia Group A?
What is hyperlipidemia Group A?
Hyperlipidemia is a major risk factor for heart disease. It refers to excess levels of LDL cholesterol and triglycerides in the blood. Doctors consider low-density lipoprotein (LDL) as bad cholesterol and high-density lipoprotein (HDL) as good cholesterol.
What is the main causes of Type II Hyperlipoproteinemia?
Secondary hyperlipoproteinemia is the result of other health conditions that lead to high levels of lipids in your body….Causes of hyperlipoproteinemia
- diabetes.
- hypothyroidism.
- pancreatitis.
- use of certain drugs, such as contraceptives and steroids.
- certain lifestyle choices.
What is the reason of Type I hyperlipoproteinemia?
Type I hyperlipoproteinemia is the best-characterized genetic cause of hypertriglyceridemia and is caused by a deficiency or defect in either the enzyme lipoprotein lipase or its cofactor, apo C-II.
Which lipid component is elevated in type IIa Hyperlipidaemia?
Type IIb. The high VLDL levels are due to overproduction of substrates, including triglycerides, acetyl-CoA, and an increase in B-100 synthesis. They may also be caused by the decreased clearance of LDL.
How serious is hyperlipidemia?
If you have hyperlipidemia, you have too many fats, like cholesterol and triglycerides, in your blood. Over time, this condition can lead to serious problems, including heart attack, stroke, and peripheral artery disease. The good news is that hyperlipidemia can be treated and, in some cases, prevented.
What is Hyperlipoproteinemia type II?
A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins).
What is Type 2 hypercholesterolemia?
Familial hypercholesterolemia (FH), also known as familial hyperlipoproteinemia type 2 or Fredrickson class 2a hyperlipidemia, is an autosomal dominant-inherited genetic disorder that leads to elevated blood cholesterol levels. Typically, the patient inherits only 1 of the defective genes, making him heterozygous.
What activates LCAT?
LCAT is activated by several apolipoproteins (apoAI and others) and uses the phospholipid lecithin (phosphatidylcholine) and free cholesterol as substrates to generate lysolecithin (lysophosphatidylcholine) and cholesteryl ester. Most of the cholesteryl esters in lipoproteins are derived from LCAT activity.
What is Type 4 hyperlipidemia?
Familial hypertriglyceridemia (type IV familial dyslipidemia) is a disorder characterized by the overproduction of very low-density lipoproteins (VLDL) from the liver. As a result, the patient will have an excessive number of triglycerides and VLDL on the lipid profile that can cause acute pancreatitis.
What is the best treatment for hyperlipidemia?
The basis of treating hyperlipidemia remains diet, physical exercise and weight reduction. Olive oil and nuts have been shown to be beneficial. Statins remain first line drug treatment. Further treatment options are ezetimibe, bile acid sequestrants, fibrates and fish oil.
Can hyperlipidemia go away?
Hyperlipidemia is treatable, but it’s often a life-long condition. You’ll need to watch what you eat and also exercise regularly. You might need to take a prescription medication, too.
What kind of disease is type II hyperlipoproteinemia?
Type II hyperlipoproteinemia: It is characterized by marked hypercholesterolemia. It includes several genetic diseases, such as familial hypercholesterolemia due to mutation of the gene for the LDL receptor and some diseases that may lead to the elevation of LDL and cholesterol.
What are the signs and symptoms of hyperlipoproteinemia?
Other signs and symptoms of hyperlipoproteinemia include: pancreatitis (type 1) abdominal pain (types 1 and 5) enlarged liver or spleen (type 1) lipid deposits or xanthomas (type 1) family history of heart disease (types 2 and 4)
What does Apo E2 stand for in hyperlipoproteinemia?
Subjects with this disorder show a mixed hyperlipidaemia, often with approximately equal plasma concentrations of cholesterol and triglycerides. The predominant defect found in most subjects with the condition is the presence of apo E2, which displays a recessive mode of inheritance.
How is hyperlipoproteinemia treated in people with diabetes?
Treatment for hyperlipoproteinemia will depend on which type you have. When the condition is the result of hypothyroidism, diabetes, or pancreatitis, treatment will take the underlying disorder into account. Your doctor may prescribe medications like the following to help lower lipid levels: