What drug classification is lovastatin?
What drug classification is lovastatin?
Lovastatin is in a class of medications called HMG CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
What is the chemical name for lovastatin?
Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease….Lovastatin.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 75330-75-5 |
| PubChem CID | 53232 |
| IUPHAR/BPS | 2739 |
What is another name for lovastatin?
What Is Mevacor? Mevacor (lovastatin) is a cholesterol-lowering medication called a statin prescribed to treat elevated blood cholesterol levels. Mevacor is available in generic form.
How is lovastatin metabolized?
Lovastatin is metabolized into its active form beta-hydroxy acid in the stomach and functions to competitively inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme is involved in the rate-limiting step of cholesterol synthesis.
What are the side effects of lovastatin?
Side Effects
- Bladder pain.
- bloody or cloudy urine.
- chest tightness.
- difficult, burning, or painful urination.
- difficulty with moving.
- frequent urge to urinate.
- joint pain or swelling.
- muscle ache, cramp, spasm, stiffness, pain, tenderness, or weakness.
Is lovastatin still available?
MEVACOR (lovastatin) tablets, 20 mg and 40 mg, are currently listed in the “Discontinued Drug Product List” section of the Orange Book.
Which is better Lipitor or lovastatin?
Atorvastatin is generally considered a more potent drug than lovastatin for lowering LDL-cholesterol levels. However, atorvastatin may carry a higher risk of myopathy in higher doses compared to lovastatin.
What is the side effect of lovastatin?
Call your doctor right away if you have a headache, stomach pain, vomiting, dark urine, loss of appetite, weight loss, general feeling of tiredness or weakness, light-colored stools, upper right stomach pain, or yellow eyes or skin.
Can you take lovastatin on an empty stomach?
It is best to take this medicine at bedtime, with a low-fat meal or snack. Do not take it on an empty stomach.
What makes a BCS Class 1 drug bioavailable?
BCS class I compounds (high solubility and permeability) are unlikely to show bioavailability/bioequivalence issues. Therefore, for BCS class I drugs, in vitro dissolution studies are thought to provide sufficient information to assure in vivo product performance making full in vivo bioavailability/bioequivalence studies unnecessary.
Which is more bioavailable RyR or pure lovastatin?
RYR product extracts also show higher lovastatin absorption than pure lovastatin in a model of intestinal absorption using cultured Caco-2 cells ( Chen et al., 2012 ). Thus, the oral bioavailability of lovastatin in RYR products may be different from that of lovastatin in lovastatin tablets.
What kind of drug is simvastatin made out of?
Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus; The drug is the form of an inactive lactone that is hydrolized after ingestion to produce the active agent.
Where are the metabolites of simvastatin located?
8.9 Human Metabolite Information 1 8.9.1 Metabolite Description. Simvastatin is a hypolipidemic drug belonging to the class… 2 8.9.2 Tissue Locations. 3 8.9.3 Cellular Locations. 4 8.9.4 Metabolite Pathways. Simvastatin is used as a medication or supplement.