Which apparatus is used for disintegration test?
Which apparatus is used for disintegration test?
Disintegration Tester is a solid state instrument designed for the accurate estimation of disintegration time of tablets as per IP/USP standards. The instrument is designed to test two batches of six tablets, simultaneously. The unit is extremely useful for pharmaceutical industries.
How many types of dissolution apparatus are there?
There are seven USP-defined types of dissolution apparatus: baskets, paddles, reciprocating cylinders, flow through cells, paddle over disk types, cylinders, and reciprocating holders.
What is 5.3 disintegration test?
11. This test is provided to determine whether tablets or capsules disintegrate within the prescribed time. 12. when placed in a liquid medium under the experimental conditions presented below.
What is tablet disintegration apparatus?
Tablet Disintegration Test Apparatus is microprocessor based instrument designed to be used by pharmaceutical industry for accurate determination time of tablets and capsules as per IP/BP/USP standards, The Disintegration Test Apparatus helps in evaluation of disintegration capability of formulations (ex: tablets) and …
How is disintegration test done?
Method. Put one tablet into each tube, suspend the assembly in the beaker containing 0.1 M hydrochloric acid and operate without the discs for 2 hours, unless otherwise stated in the individual monograph. Remove the assembly from the liquid. The tablets pass the test if all six have disintegrated.
What is difference between disintegration and dissolution?
Disintegration is a process of breaking down a substance into tiny fragments to improve its solubility in a solvent. Dissolution, on the other hand, is a process through which solutes dissolve in a solvent. Dissolution is also used predominantly in pharmaceutical industries to check how soluble a drug is in the body.
What is disintegration time?
Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions. In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.
How do you use disintegration apparatus?
Method. Put one tablet into each tube, suspend the assembly in the beaker containing 0.1 M hydrochloric acid and operate without the discs for 2 hours, unless otherwise stated in the individual monograph. Remove the assembly from the liquid.
What is the use of disintegration test?
The disintegration test is used to show how quickly the tablet breaks down into smaller particles, allowing for a greater surface area and availability of the drug when taken by a patient.
What is the description of disintegration?
: the act or process of disintegrating or the state of being disintegrated: such as. a : the breaking down of something into small particles or into its constituent elements Some glaciers have been destabilized by warmer ocean waters.
What kind of apparatus is used for disintegration test?
Disintegration Test for Tablets and Capsules. Apparatus. The apparatus consists of a basket-rack assembly, a 1-liter beaker, a thermostatic arrangement for heating the fluid and a mechanical device for raising and lowering the basket in the immersion fluid at a constant frequency rate. Basket-rack assembly.
What are the different types of Dissolution Apparatus?
Dissolution is very crucial as it is the rate limiting factor. Rotating Basket USP1 is adopted in 1970 the rotating basket method of dissolution testing was the first official method. The apparatus consists of a metallic drive shaft connected to the cylindrical basket.
What is the disintegration test for capsules and tablets?
Use the apparatus for tablets and capsules described above. Put one tablet into each tube, suspend the assembly in the beaker containing 0.1 M hydrochloric acid and operate without the discs for 2 hours, unless otherwise stated in the individual monograph. Remove the assembly from the liquid.
When to use Fenton’s reagent for disintegration?
If dewatering properties of sludge are the aim of disintegration, usually short process times are used that are not longer than 90 min. The use of Fenton’s reagent allows decreasing the capillary suction time as well as the specific resistance to filtration by even more than 90% ( Zhen et al., 2014; Lu et al., 2003; Buyukkamaci, 2004 ).