What is the structure of vinblastine?
What is the structure of vinblastine?
C46H58N4O9
Vinblastine/Formula
Is vinblastine a Vesicant?
Vinblastine is given through a vein by intravenous injection (IV push) or infusion (IV). There is no pill form. Vinblastine is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein.
How does vinblastine affect mitosis?
Both vincristine and vinblastine bind to the microtubular proteins of the mitotic spindle and prevent cell division during the anaphase of mitosis. They arrest mitosis and cause cell death. The drugs are therefore M-phase cell-cycle specific and their effects are therefore limited to dividing cells.
Why is vincristine being discontinued?
It is ramping up production of vincristine—often used with other drugs to treat leukemia, brain tumors and lymphomas—after Teva in July notified the FDA that it had made the “business decision” to discontinue production. Its move has left pediatric oncologists scrambling to find supplies.
Is vincristine a strong chemo drug?
Vincristine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Vincristine is classified as a plant alkaloid.
Is vinblastine used in chemotherapy?
Drug type: Vinblastine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as a “plant alkaloid.” (For more detail, see “How vinblastine works” section below).
What drug classification is vinblastine?
Vinblastine is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in your body.
What is the antitumor activity of vinblastine?
The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
How is vinblastine similar to catharanthine and vindoline?
Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959.
What kind of alkaloid is vinblastine sulfate?
Vinblastine Sulfate is the sulfate salt of vinblastine, a natural alkaloid isolated from the plant Catharanthus roseus (Madagascar periwinkle) with antineoplastic properties. Vinblastine disrupts microtubule formation and function during mitosis and interferes with glutamic acid metabolism. (NCI04) Vinblastine sulfate appears as an anticancer drug.
How long does vinblastine stay in the body?
Vinblastine is rapidly distributed from the plasma to tissues, primarily to the lung, liver, spleen, and kidneys. The elimination half-life of vinblastine is approx 29 h, with very little drug remaining in the body at 48 h 26, 27 .