Is mediastinal seminoma curable?
Is mediastinal seminoma curable?
Mediastinal seminomas are a relatively rare malignant disorder that is best treated by an interprofessional team. These tumors are usually curable with aggressive chemotherapy and radiation. Surgical intervention is used in some cases when the tumor is small and localized.
Is pure seminoma curable?
Seminoma, 80% of which are diagnosed at stage I (Table 1), is highly sensitive to both radiotherapy (RT) and chemotherapy (CHT) and, therefore, unlike many malignant neoplasms, cure is an expected outcome in the majority of cases, even with metastatic disease at presentation [3].
What is the prognosis of seminoma?
5-year relative survival rates for testicular cancer
| SEER stage | 5-year relative survival rate |
|---|---|
| Localized | 99% |
| Regional | 96% |
| Distant | 73% |
| All SEER stages combined | 95% |
What was the survival rate for mediastinal seminoma?
Mediastinal seminomas were first discovered in the late 1950s, and great progress has been made in curing patients of this disease and prolonging life. The 5-year survival rate has increased to 87% to 100%, similar to the results of testicular seminomas.
Can a mediastinal seminoma be a germ cell tumor?
Malignant germ cell tumors of the mediastinum are rare, accounting for approximately 10% of all mediastinal tumors. These tumors occur almost exclusively in males, and the age at presentation is generally 20-35 years. [ 1] More than one third of all malignant germ cell tumors are pure seminomas.
What is the prognosis for seminoma extragonadal germ cell tumors?
A seminoma extragonadal germ cell tumor is in the intermediate prognosis group if: the tumor has spread to organs other than the lungs; and the level of AFP is normal; β-hCG and LDH may be at any level.
Can a mediastinal seminoma be treated with cisplatin?
Mediastinal seminoma is a malignant germ cell tumor in the mediastinum. The tumor usually occurs in the anterior-superior mediastinum in males aged 20-40 years old. The first-line treatment is with cisplatin based chemotherapy.