What does Alport syndrome cause?
What does Alport syndrome cause?
Alport syndrome is a disease that damages the tiny blood vessels in your kidneys. It can lead to kidney disease and kidney failure. It can also cause hearing loss and problems within the eyes. Alport syndrome causes damage to your kidneys by attacking the glomeruli.
What age does Alport syndrome present?
Hearing loss typically develops during late childhood or early adolescence, and most affected individuals become deaf by age 40. Alport syndrome is also characterized by specific eye changes….Symptoms.
| Medical Terms | Other Names | Learn More: HPO ID |
|---|---|---|
| Corneal erosion | Damage to outer layer of the cornea of the eye | 0200020 |
Is Alport syndrome curable?
Alport syndrome is an inherited disorder that is characterized by progressive kidney damage, hearing problems, and eye abnormalities. There is currently no cure for Alport syndrome and treatments are limited, but research is ongoing and various therapies are used to help patients manage its symptoms.
What are the first signs of kidney disease?
Signs of Kidney Disease
- You’re more tired, have less energy or are having trouble concentrating.
- You’re having trouble sleeping.
- You have dry and itchy skin.
- You feel the need to urinate more often.
- You see blood in your urine.
- Your urine is foamy.
- You’re experiencing persistent puffiness around your eyes.
How common is Alport syndrome?
Affected Populations Alport syndrome is estimated to affect approximately 1 in 5,000-10,000 people in the general population in the United States, which means that approximately 30,000-60,000 people in the United States have the disorder.
Who treats Alport syndrome?
It is very important for people with Alport syndrome to be examined regularly by a nephrologist so that effects of kidney disease, such as hypertension (high blood pressure), can be identified early and treated. Regular evaluations of hearing and vision are also important.
How rare is Alport syndrome?
Alport syndrome is estimated to affect approximately 1 in 5,000-10,000 people in the general population in the United States, which means that approximately 30,000-60,000 people in the United States have the disorder.
How bad is Alport syndrome?
Alport syndrome is estimated to account for 3% of children with chronic kidney disease and 0.2% of adults with end-stage renal disease in the United States. In XLAS, males are affected more severely than females. In the autosomal forms of Alport syndrome, males and females are affected with equal severity.
Is Alport syndrome fatal?
Most affected individuals will experience end-stage renal disease and deafness by age 40. Without regular dialysis treatments or renal transplant, a patient’s life expectancy may be reduced.
Does Alport syndrome cause pain?
Corneal erosion in which there is loss of the outer layer of the covering of the eyeball, leading to pain, itching, or redness of the eye, or blurred vision. Abnormal coloring of the retina, a condition called dot-and-fleck retinopathy. It doesn’t cause vision problems, but can help diagnose Alport syndrome.
What is the life expectancy of someone with Alport syndrome?
Alport Syndrome (COL4A5-Related) (COL4A5) Life expectancy is in middle age; however, new treatments are being tested that delay kidney failure and therefore extend life expectancy. Although symptoms are similar between all people affected by Alport syndrome, null variants are associated with earlier progression to end-stage renal disease.
Is there any natural treatment for alport syndrome?
Compared with other natural treatment for alport syndrome, acupuncture shows specific effects in alleviating its symptoms. By stimulating the specific acupoints, this therapy can help lower blood pressure, strengthen kidney function and improve immunity for patients with alport syndrome.
Does Alport syndrome have a cure?
There is no cure for Alport syndrome, but close follow up with your doctor can help to reduce or prevent damage to organs like the kidneys, eyes, and ears. You should go see your primary care doctor in the next 24 hours. Diagnosis is based on having the right symptoms, genetic testing, and doing blood tests to determine kidney function.
How does Alport syndrome affect hearing?
Alport syndrome also causes sensorineural hearing loss, or hearing loss that is due to the inner ear or the nerves not working properly. Hearing loss typically develops during late childhood or early adolescence, and most affected individuals become deaf by age 40.