How does pancytopenia affect the body?
How does pancytopenia affect the body?
Pancytopenia is serious and should not be ignored. Without treatment, it can lead to life-threatening symptoms that affect the entire body such as oxygen shortage and immune system problems.
What are the common manifestation of patients with pancytopenia?
The commonest clinical manifestations of Pancytopenia are usually Fever (86.7%), fatigue (76%), dizziness (64%), weight loss (45.3%), anorexia (37.3%), night sweats (28%), pallor (100%), bleeding (38.7%), splenomegaly (48%), hepatomegaly (21.3%), and lymphadenopathy is (14.7%).
What is the most common drug that causes pancytopenia?
Medications that can affect bone marrow function include chloramphenicol, chemotherapy drugs, thiazide diuretics, anti-epileptic drugs, colchicine, azathioprine, and non-steroidal anti-inflammatory drugs (NSAIDs). The list here covers just some of the potential disease-related pancytopenia causes.
Is pancytopenia a cancer?
In some parts of the world, pancytopenia is caused by poor nutrition. In North America, most cases of pancytopenia are related to the uncontrolled growth of cells. These are called neoplastic conditions, and they can be cancerous or noncancerous.
What infections can cause pancytopenia?
Pancytopenia causes and risk factors
- Epstein-Barr virus, which causes mononucleosis.
- cytomegalovirus.
- HIV.
- hepatitis.
- malaria.
- sepsis (a blood infection)
Can Vitamin B12 deficiency cause pancytopenia?
Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency.
What virus causes pancytopenia?
The second major cause of infectious pancytopenia is through the effect of viral infections. Essentially, any virus can cause suppression of multiple cell lines but the herpes viruses, including Epstein-Barr virus (EBV) and cytomegalovirus (CMV), as well as viral hepatitides are the most commonly implicated.
Can pancytopenia go away?
The prognosis of pancytopenia depends largely upon its cause. Thankfully, we now have treatments such as transfusions and stimulating factors to help with the specific blood cell deficiencies while the underlying condition is evaluated and treated.
Can pancytopenia be cured?
Treatments for pancytopenia include drugs that suppress the immune system (immunosuppressant drugs) and bone marrow stimulant drugs, blood transfusion, bone marrow transplant, and stem cell replacement therapy.
Can bacterial infection cause pancytopenia?
Numerous viruses, bacteria, protozoa, and fungi are also known to cause pancytopenia via an acquired HLH syndrome. Patients with this disease present similarly to those with primary HLH, as described before, and are diagnosed using the same criteria.
Does pancytopenia go away?
What is pancytopenia cancer?
Pancytopenia is also seen in cancers like acute myeloid leukemia which is a cancer of bone marrow and multiple myeloma which is the cancer of the plasma cells (a type of white blood cell). It is also seen in infections and in cases of enlarged/overactive spleen.
What is pancytopenia anemia?
pancytopenia(Noun) A form of anemia in which there is a reduction in the numbers of red blood cells, white blood cells and platelets.
What is pancytopenia definition?
Definition of pancytopenia : an abnormal reduction in the number of erythrocytes, white blood cells, and blood platelets in the blood also : a disorder (such as aplastic anemia ) characterized by such a reduction