What does it mean when your beta-2 microglobulin is high?
What does it mean when your beta-2 microglobulin is high?
People with cancers of the bone marrow and blood often have high levels of B2M in their blood or urine. These cancers include multiple myeloma, lymphoma, and leukemia. High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.
Is beta-2 microglobulin the same as beta globulin?
Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins. Examples of beta globulins include: beta-2 microglobulin.
What is a normal beta 2 microglobulin?
Urine beta2 microglobulin values indicate renal filtration disorders. Measurement of values in both serum and urine can help distinguish a problem of cellular activation from a renal disorder. Normal findings : Blood: 0.70-1.80 mcg/mL.
What is the Beta 2 microglobulin test?
This beta-2 microglobulin (B2M) test is used as a tumor marker for some people with blood cell cancers. It is not diagnostic for a specific disease, but it has been associated with the amount of cancer present (tumor burden) and can give a healthcare practitioner additional information about someone’s likely prognosis.
What causes elevated beta globulin levels?
There are lot many causes which can cause high globulin levels.Most common of them are:chronic Inflammatory diseases (ex: TB, Syphilis),multiple myeloma,leukemias,autoimmune disease, such as rheumatoid arthritis,lupus,autoimmune hepatitis,Kidney disease(diabetes can also cause kidney disease called diabetic nephropathy ),liver disease.
What does elevated beta 2 mean?
Beta 2 micro globulin is a component molecule of the cells in the human body. Its levels tend to be elevated when a person is suffering from a particular type of cancer. This feature of the Beta 2 micro globulin makes it useful in the diagnosis of various types of diseases.
What is the normal range for beta globulin?
Normal range of globulins is 2.3-3.5 gm/dL. Alpha globulin range is 0.2-0.3 g/L and optimal beta globulin range is 0.7-1.0 g/L.
What is B2 microglobulin test?
The beta-2 microglobulin ( B2M ) blood test is used to help detect kidney damage and follow kidney disorders, to help evaluate the severity and prognosis of certain cancers such as multiple myeloma and some lymphomas, and it is sometimes used to monitor people who are exposed to cadmium.