What is the difference between pyogenic granuloma and peripheral giant cell granuloma?
What is the difference between pyogenic granuloma and peripheral giant cell granuloma?
The pyogenic granuloma can occur anywhere in the oral cavity, whereas the peripheral ossifying fibroma and peripheral giant cell granuloma only occur on the gingiva or alveolar mucosa. The clinical appearance, treatment, and prognosis are the same for all 3 entities.
What is peripheral giant cell granuloma?
Peripheral giant cell granuloma (PGCG) is the most common oral giant cell lesion appearing as a soft tissue extra-osseous purplish-red nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells.
What is the difference between central and peripheral giant cell granuloma?
Giant cell lesions (GCG) are a group of varied lesions that contain a multitude of multinucleated, osteoclast like giant cells within connective tissue stroma. These include giant cell granulomas which may be central (CGCG), if they lie within the jaw bone, or, peripheral (PGCG) if they lie within the soft tissue.
What is peripheral fibroma?
Peripheral ossifying fibroma (POF) is a non-neoplastic entity, which occurs on the gingiva in response to trauma or irritation. It is a reactive lesion of connective tissue and is not the soft-tissue counterpart of central ossifying fibroma.
How do you treat peripheral giant cell granulomas?
The peripheral giant cell granuloma is best treated by complete surgical excision, with care taken to excise it at its base [14]. The treatment of PGCG comprises surgical resection with elimination of the entire base of the lesion in addition to the eradication of the underlying source of irritant factors [2, 3].
Is peripheral giant cell granuloma malignant?
It can be sessile or pedunculated with the size usually being less than 2 cm. The lesion has a 60% gender predilection to females. The prevalence of the peripheral giant-cell granuloma is highest around 50 – 60 years of age….
| Peripheral giant-cell granuloma | |
|---|---|
| Specialty | Dentistry, ENT surgery |
What causes a peripheral giant cell granuloma?
The cause of peripheral giant cell granuloma is unknown, although local irritation due to dental plaque or calculus, periodontal disease, poor dental restorations, ill-fitting dental appliances, or dental extractions has been suggested to contribute to the development of the lesion.
Is central giant cell granuloma painful?
Clinical Presentation: There is a rare, aggressive type that produces a large, fast-growing lesion, despite the benign histologic appearance. The aggressive type often presents with pain and rapid growth and has a high recurrence rate.
What causes peripheral ossifying fibroma?
Synonyms of POF are peripheral cementifying fibroma, calcifying or ossifying fibroid epulis, and peripheral fibroma with calcification. These lesions may arise as a result of irritants such as trauma, microorganisms, plaque, calculus, faulty restorations, and dental appliances [2, 3].
What causes ossifying fibroma?
Still, ossifying fibromas can occur for patients of any age and sex. Trauma, irritation caused by dental restorations, and plaque underneath the gums might also all play a role in development, but the precise cause is still unknown.
Is peripheral giant cell granuloma painful?
However, PGCG has a typical bluish – red hue in contrast to pyogenic granuloma that has a characteristic bright red color. The lesion is usually asymptomatic; however, repeated trauma due to occlusion can lead to its growth with eventual ulceration and secondary infection. Rarely, the lesion is painful in nature.
Can a neoplasia be a peripheral ossifying fibroma?
Nancy Burkhart, RDH, reviews a case where the diagnosis in oral pathology could be either a peripheral ossifying fibroma or a pyogenic granuloma. Neoplasia refers to an uncontrolled growth of tissue or cells not under physiologic control that may be either malignant or benign.
How is pyogenic granuloma similar to peripheral ossifying fibroma?
The pyogenic granuloma (PG) may become more fibrotic as the lesion ages, making it clinically resemble the peripheral ossifying fibroma (POF). The pyogenic granuloma often appears red and ulcerative and bleeds. The same can be true for the POF because they can become traumatized and may bleed.
Is there such a thing as peripheral giant cell granuloma?
Clinically, it bears resemblance to pyogenic granuloma, peripheral ossifying fibroma and many other peripheral lesions seen in the oral cavity, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, but still carries a lot of ambiguity.
Where does metaplastic bone formation occur in peripheral giant cell granuloma?
Metaplastic or osteoblastic new bone formation may be seen, usually in the lower third of the lesion. Dystrophic calcification may be present as well. Occasional lesions show an admixture of tissue types compatible with peripheral giant cell granuloma, POF, and pyogenic granuloma, presumably because of the common pathoetiology of these lesions.