How a nanomaterial can be used for drug delivery?
How a nanomaterial can be used for drug delivery?
Through the manipulation of size, surface characteristics and material used, the nanoparticles can be developed into smart systems, encasing therapeutic and imaging agents as well as bearing stealth property. Further, these systems can deliver drug to specific tissues and provide controlled release therapy.
Are nanoparticles bad for the body?
Out of three human studies, only one showed a passage of inhaled nanoparticles into the bloodstream. Materials which by themselves are not very harmful could be toxic if they are inhaled in the form of nanoparticles. The effects of inhaled nanoparticles in the body may include lung inflammation and heart problems.
What are the pros and cons of nanoparticles?
Advantages and Disadvantages of using nanoparticles
- Large surface area to volume ratio makes them effective catalysts.
- So small they can enter the skin and therefore the bloodstream.
- Nanoparticles in sun creams can be absorbed deeper into the skin.
- Large surface can make them too reactive and explosive in some situations.
What are the sizes of nanoparticles?
A nanoparticle is a small particle that ranges between 1 to 100 nanometres in size. Undetectable by the human eye, nanoparticles can exhibit significantly different physical and chemical properties to their larger material counterparts.
How big do nanoparticles need to be for drug delivery?
Although the definition identifies nanoparticles as having dimensions below 0.1 μm or 100 nm, especially in the area of drug delivery relatively large (size >100 nm) nanoparticles may be needed for loading a sufficient amount of drug onto the particles.
How are nanomaterials used in drug delivery systems?
For instance, gold nanoparticles are used as biomarkers and tumor labels for various biomolecule detection procedural assays. Regarding the use of nanomaterials in drug delivery, the selection of the nanoparticle is based on the physicochemical features of drugs.
How are nanoparticles used in biomedicine and medicine?
The field of biomedicine comprising nanobiotechnology, drug delivery, biosensors, and tissue engineering has been powered by nanoparticles [ 17 ]. As nanoparticles comprise materials designed at the atomic or molecular level, they are usually small sized nanospheres [ 18 ].
What are the aims of nanoparticle entrapment of drugs?
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. For these aims, creation of long-lived and target-specific nanoparticles is needed.