How do you test the hardness of a tablet?
How do you test the hardness of a tablet?
The Pfizer tester compresses tablet between a holding anvil and a piston connected to a force-reading gauge when its plier-like handles are gripped. The Erweka tester tests a tablet placed on the lower anvil and a weight moving along a rail transmits pressure slowly to the tablet.
What is the hardness of a tablet?
As mentioned in both US and European Pharmacopeia, the term “hardness” is actually misleading in a scientific sense, but commonly used as a synonym for breaking force or resistance to crushing strength. In simple terms, tablet hardness is the force (load) required to break a tablet.
What range is hardness required for good compressible tablet?
Although there is not definite number for the hardness of the tablet, there is a recommended range which is most likely sufficient for handling, this is between 1.5-4 MPa or approx 15-40 Newton.
Which quality test for tablets is not official in LP?
NON OFFICIAL TESTS: HARDNESS (CRUSHING STRENGTH): Hardness (crushing strength): It is the load required to crush the tablet when placed on its edge. Why do we measure hardness? To determine the need for pressure adjustments on the tableting machine.
What affects the hardness of a tablet?
The types of binders used, the nature of the active ingredient(s), and the composition of the ingredient(s) in the tablet will affect the hardness of the tablet; the tablet press speed, granulation flow, and air in the powder can also potentially affect tablet hardness (1).
What does hardness depend on?
Hardness is dependent on ductility, elastic stiffness, plasticity, strain, strength, toughness, viscoelasticity, and viscosity. Common examples of hard matter are ceramics, concrete, certain metals, and super hard materials, which can be contrasted with soft matter.
How can I reduce the hardness of my tablet?
Most recent answer
- Use colloidal silicon dioxide extragranularly, will give higher hardness and solve friability issue For DC Method.
- Use slugging process For dry granulation method.
- Use dry binder (HPC)- For DC Method.
- Use Gelatin with starch paste will give excellent hardness For wet granulation method.
Which test is performed to check the amount of drug in a tablet formulation?
Dissolution and Drug Release Tests Dissolution is the process in which a substance forms a solution. Dissolution testing measures the extent and rate of solution formation from a dosage form, such as tablet, capsule, ointment, etc.
What are the importance of the tablet hardness test?
These tablet hardness tests provide a meaningful picture as to the amount of force required to fracture the solid-dose tablet. This knowledge will be useful in gauging the tablet’s resistance to damage that might occur during production handling, packaging, and storage.
Why is the hardness test important?
The application of hardness testing enables you to evaluate a material’s properties, such as strength, ductility and wear resistance, and so helps you determine whether a material or material treatment is suitable for the purpose you require.
What are examples of hardness?
Hardness is a measure of how much a material resists changes in shape. Hard things resist pressure. Some examples of hard materials are diamond, boron carbide, quartz, tempered steel, ice, granite, concrete. Ability of material to resist wear, tear, scratching, abrasion cutting is called hardness.
How does hardness affect dissolution?
as the compression force increases the hardness of the tablet increases and the porosity decreases which may result in a decreased water ingression and this will result in a slower rate of dissolution.
Which is the best hardness tester for tablets?
Lab.line H-Series – Tablet Hardness Tester The H-Series Tablet Hardness Testers is a manual laboratory testing devices in the new LAB.line design combine the latest technology and usability. Rounded shapes, generous radii and smooth…
How are newtons used in tablet hardness testing?
Units of measurement. Newton (N) – The Newton is the SI unit of force; the standard for tablet hardness testing. 9.807 Newtons = 1 kilogram (at one G, earth surface gravity). Pound (lb) – Technically a unit of force but can also be used for mass under earth gravity. Sometimes used for tablet strength testing in North America,…
Which is the correct definition of tablet hardness?
The term tablet hardness is commonly used in the pharmaceutical and nutraceutical industry. However, Tablet hardness is somewhat misleading in that hardness is more accurately defined as the ability of a material to resist the penetration of a probe.
How is the hardness of a pan determined?
So, an acceptable tablet hardness or friability for a small coating pan may not be sufficient for a larger pan. A tablet hardness tester is used to determine the edge-to-edge (diametral) tablet hardness. Typical hardness measurement units include: kiloponds (kp), Strong Cobb Units (SCU), and Newtons (N).