How is serotonin transported around the body?
How is serotonin transported around the body?
The action of serotonin in the synapse is terminated by reuptake into the presynaptic terminal via an energy-dependent transporter molecule, the serotonin transporter. In the brain, the serotonin transporter is specifically localized in serotonin neurons and has been used as a marker for these cells.
What drug blocks the serotonin transporter?
Sertraline and fluoxetine are selective serotonin reuptake inhibitors (SSRIs) widely-prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT).
Is serotonin an active or passive transporter?
Serotonin transporter assumes the active co-uptake of 5-HT and Cl- ion using as the energy force the Na+ gradient created by the plasma membrane Na/K ATPase (Rudnick, 1977).
What does the 5 HTT gene do?
The 5-HTT gene has been associated with both depression and autism. The serotonin transporter protein (5-HTT/SLC6A4) transports the neurotransmitter serotonin from synapses to presynaptic neurons. It seems to be an important component in the physiological response to cocaine and amphetamines.
What do serotonin transporters do?
The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the presynaptic neuron.
What gene is responsible for serotonin?
The gene that encodes the serotonin transporter is called solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4, see Solute carrier family). In humans the gene is found on chromosome 17 on location 17q11.
Where are serotonin transporters found?
Serotonin transporters (5-HTT or SERT) and receptors (5-HT1–7) are located in the central, peripheral, and enteric nervous systems, and have been identified in several other peripheral tissues including bone.
Is Serotonin transporter genetic?
The human serotonin transporter (5-HTT), encoded by a single gene on chromosome 17q11. 2, is expressed in brain and blood cells. 5-HTT is implicated in mood and anxiety regulation, and is where antidepressant and antianxiety drugs initially act in the brain.