Is Dicumarol a competitive inhibitor?
Is Dicumarol a competitive inhibitor?
Dicoumarol, a competitive inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), increases intracellular superoxide and affects cell growth of tumor cells.
Is Dicumarol an anticoagulant?
Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).
What is Dicumarol prescribed for?
Introduction. Dicumarol, like warfarin, is a 4-hydroxycoumarin-derived anticoagulant that is used for the treatment of thromboembolic conditions. It was the first of the oral anticoagulants to be isolated and used clinically.
What are the side effects of Dicumarol?
If experienced, these tend to have a Severe expression i
- a sudden decrease in adrenal gland function.
- low levels of white blood cells.
- canker sores.
- decreased kidney function.
- inflammation of the skin due to an allergy.
- itching.
- hives.
- pain in the foot.
Is Dicoumarol still used?
Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs.
Is Phenindione an oral anticoagulant?
Phenindione is an anticoagulant. It will be prescribed if you have a harmful clot in your blood, or if you are at risk of having a harmful blood clot. You may be given a yellow booklet about your anticoagulant treatment; read this carefully….About phenindione.
| Type of medicine | An anticoagulant |
|---|---|
| Available as | Tablets |
What is the use of Bishydroxycoumarin?
USE OF BISHYDROXYCOUMARIN (DICUMAROL) FOR PREVENTION OF POSTOPERATIVE THROMBOEMBOLISM: A Study of Twenty-Seven Hundred Consecutive Surgical Patients | JAMA Surgery | JAMA Network.
What is vitamin K also called?
Vitamin K1, also called phylloquinone, is mostly found in plant foods like leafy green vegetables. It makes up about 75–90% of all vitamin K consumed by humans ( 2 ).
What are the oral anticoagulant drugs?
In the last few years, FDA has approved three new oral anticoagulant drugs – Pradaxa (dabigatran), Xarelto (rivaroxaban), and Eliquis (apixaban). Like warfarin, all three are ‘blood thinners’ that reduce the overall risk of stroke related to atrial fibrillation but they also cause bleeding.
Is heparin an oral anticoagulant?
Oral heparin will be a particularly appropriate anticoagulant for indications that require prophylaxis or treatment for extended periods, months or indefinitely [59].