Is naratriptan safe in pregnancy?
Is naratriptan safe in pregnancy?
This drug should not be used during pregnancy unless the benefit outweighs the risk to the fetus.
What category is Imitrex for pregnancy?
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Why is sumatriptan contraindicated in pregnancy?
Concerns have been raised about whether the use of sumatriptan late in pregnancy may be associated with preeclampsia (dangerously high blood pressure), preterm birth, low birth weight and heavy bleeding following delivery. Several studies have noticed a small increased chance for these outcomes.
Which is the best triptan to take during pregnancy?
Evidence-based information regarding sumatriptan is the most abundant, most likely because it was the prototype of the drug class and has been available for many years. Pregnancy registry data are available for 3 triptans: sumatriptan, naratriptan, and rizatriptan.
Is it safe to take sumatriptan during pregnancy?
Information on the use of sumatriptan during pregnancy is relatively more abundant, because it has been on the market longer than the other triptans and may also have a higher percentage of the market share. There are no data to suggest teratogenicity for any of the triptans, although preterm birth rates appear to be elevated.
When to use triptans for migraine headaches during pregnancy?
The authors identified 1535 pregnant women who received triptans during their pregnancies; 90% of the women used triptans in the first trimester and 65% used them during the second or third trimesters.
Can a triptan increase the risk of atonic uterus?
Triptan therapy during the second or third trimesters was associated with a small increase in the risk of atonic uterus (OR 1.4, 95% CI 1.1 to 1.8) and blood loss (> 500 mL) during labour (OR 1.3, 95% CI 1.1 to 1.5), but not with a risk of adverse fetal outcomes. 17 Regarding the use of triptans during breastfeeding, human data remain scarce.