What does tartrate resistant acid phosphatase do?
What does tartrate resistant acid phosphatase do?
The ACP5 gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells.
What constitutes a positive result with the acid phosphatase tartrate resistant stain?
A positive result means that your bones are breaking down for some reason. If you have other tests that show you have hairy cell leukemia, it will help confirm the diagnosis.
Do osteoclasts produce tartrate?
3 Tartrate-Resistant Acid Phosphatase Type 5b. TRAP-5b is produced by osteoclasts and is considered a good marker of bone resorption [105].
What does TRAP do in osteoclasts?
Cell growth and differentiation factor. TRAP is associated with osteoclast migration to bone resorption sites, and, once there, TRAP is believed to initiate osteoclast differentiation, activation, and proliferation. This hypothesis was formed from the examination of the bone structure of TRAP-null mice.
Where is acid phosphatase found?
Acid phosphatase is a ubiquitous lysosomal enzyme that hydrolyses organic phosphates at an acid pH. Although the postpuberteral prostatic epithelial cell contains a uniquely high concentration of acid phosphatase, cellular components of bone, spleen, kidney, liver, intestine, and blood also contain this enzyme.
What is TRAP positive?
Tartrate resistant acid phosphatase (TRAP) positive cells in rheumatoid synovium may induce the destruction of articular cartilage.
What does TRAP test mean?
Tartrate resistant acid phosphatase
Definition. Tartrate resistant acid phosphatase (TRAP) is a test performed on blood cells or bone marrow (biopsy) to confirm a diagnosis of hairy cell leukemia. This test can also be done on blood plasma to look for signs of bone breakdown.
What stimulates osteoblast activity?
Steroid and protein hormones Parathyroid hormone is a protein made by the parathyroid gland under the control of serum calcium activity. Intermittent PTH stimulation increases osteoblast activity, although PTH is bifunctional and mediates bone matrix degradation at higher concentrations.
Why do osteoclasts break down bone?
Degrading bone also allows periodic repair and remodeling for ordered growth and efficient response to mechanical loads. Osteoclasts dissolve bone mineral by massive acid secretion and secrete specialized proteinases that degrade the organic matrix, mainly type I collagen, in this acidic milieu.
Which of the following stimulates osteoclast activity?
Osteoclastic activity is stimulated by cytokines such as IL-6 and RANK and inhibited by calcitonin.
What causes osteopetrosis?
Osteopetrosis is marked by increased bone density due to a defect in bone reabsorption by cells called osteoclasts. This leads to accumulation of bone with defective architecture, making them brittle and susceptible to fracture. In some cases, this is also accompanied by skeletal abnormalities.
Is acid phosphatase a tumor marker?
Prostatic acid phosphatase is a possible tumor marker for intravascular large B-cell lymphoma.