What is a 2 compartment model?
What is a 2 compartment model?
Pharmacokinetic two-compartment model divided the body into central and peripheral compartment. The peripheral compartment (compartment 2) consists of tissues where the distribution of the drug is slower.
What is the difference between one and two-compartment model?
A one-compartment model may be used for drugs which rapidly equilibrate with the tissue compartment, e.g, aminoglycosides. A two-compartment model should be used for drugs which slowly equilibrate with the tissue compartment, e.g, vancomycin.
What is Cl F in PK?
Background: Oral clearance (CL/F) is an important pharmacokinetic parameter and plays an important role in the selection of a safe and tolerable dose for first-in-human studies. The CL/F was predicted using these approaches, and the oral AUC was then estimated using the predicted CL/F.
What is k12 and k21?
The higher the ratio k12/k21 the greater the distribution of drug into the peripheral compartment. The larger the individual values of k12 and k21 the faster is the transfer between the central and peripheral compartments and the more the body behaves as a single compartment.
Does VD affect AUC?
The Volume of distribution can go up, down, or sideways … it will not affect AUC.
What is a high VD?
A drug with a high Vd has a propensity to leave the plasma and enter the extravascular compartments of the body, meaning that a higher dose of a drug is required to achieve a given plasma concentration. (High Vd -> More distribution to other tissue) (Low Vd -> Less distribution to other tissue)
What is CL pharmacokinetics?
CL is an index of how well a drug is removed irreversibly from the circulation. As a result it determines the dose-rate (dose per unit time) required to maintain a Cp. CL only applies to drugs with first-order (exponential) kinetics, i.e. the majority of drugs.
What is extrapolated volume of distribution?
Volume of distribution (Vd) It is estimated from measurements of the total concentration of drug in the blood after a single IV injection by extrapolation of the concentration at t = 0: Vd = (amount of drug injected)/(blood concentration extrapolated at t = 0).
