What is bilateral periventricular nodular heterotopia?
What is bilateral periventricular nodular heterotopia?
content highlights. Periventricular nodular heterotopia is a brain malformation of cortical development where there is abnormal clumping of grey matter (nerve cells) along the lining of the fluid-filled brain cavities called the ventricles. PVNH seizures can be unilateral (on one side) or bilateral (on both sides).
What is gray matter heterotopia?
The grey matter heterotopias are a relatively common group of conditions characterized by interruption of normal neuronal migration from near the ventricle to the cortex, thus resulting in “normal neurons in abnormal locations” 2. They are a subset of disorders of cortical formation 3-4.
Is gray matter heterotopia a disability?
Psychiatric disorders where grey matter heterotopia has been discovered. The most common neuropsychiatric clinical picture is that of intellectual disability, which ranges from mild to severe in nature, even though many patients with GMH present with normal intellectual functioning.
What are the clinical features of periventricular heterotopia?
Periventricular (subependymal) nodular heterotopia (PNH) are malformations of cortical development (MCD) characterised by single or multiple nodules of grey matter adjacent to the lateral ventricular walls. 1 The nodules usually bulge into the ventricle and range in size from small, discrete neuronal clusters to large multinodular conglomerates.
When was periventricular leukoencephalopathy first published?
First published October 1, 1972, DOI: https://doi.org/10.1212/WNL.22.10.1094 This is a PDF-only article. The first page of the PDF of this article appears above. We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies.
How are nodular heterotopia related to epilepsy?
Both generalised and localised nodular heterotopia are attributable to abnormal neuronal migration 2 and may be isolated or associated with other cortical and brain malformations. PNH are attributable to a group of neuroblasts that seems incapable of the usual radial and tangential migration from the ventricular zone during cortical development.
What kind of neuronal defect is heterotopia?
La heterotopía neuronal es un defecto de la migración de las neuronas del cerebro en el cual estas células no completan su desplazamiento hacia la corteza del cerebro.