What is E-cadherin in breast cancer?
What is E-cadherin in breast cancer?
E-cadherin is a cell adhesion molecule that is expressed in normal breast tissue and is useful as a phenotypic marker in breast cancer, with absence of its expression frequently observed in lobular type tumors.
What is pleomorphic lobular carcinoma?
Pleomorphic lobular carcinoma (PLC) is a variant of invasive lobular carcinoma (ILC) that is described in the literature as an aggressive tumor with poor prognosis. Multiple studies have shown a decrease in overall survival when compared to classic ILC (cILC).
Is pleomorphic lobular carcinoma in situ really cancer?
Pleomorphic lobular carcinoma in situ is more likely to become invasive breast cancer and spread to other tissues in the breast than the more common form is. Pleomorphic lobular carcinoma in situ usually occurs in postmenopausal women. Also called PLCIS.
What is E-cadherin in cancer?
E-cadherin is a well-known tumor suppressor protein, and the loss of its expression in tumor cells, in association with the epithelial–mesenchymal transition (EMT), occurs frequently during tumor progression and metastasis (Cano et al., 2000 ; Yang and Weinberg, 2008 ; Nieto, 2011 ; Valastyan and Weinberg, 2011 ; Huang …
What does pleomorphic cells mean?
Pleomorphic is a word pathologists use to describe a group of cells that are very different from each other in either size, shape, or colour. For example, the cells in a tissue sample would be described as pleomorphic if some of the cells in a tissue sample were small while other were very large.
What does pleomorphic LCIS mean?
Pleomorphic means that the LCIS cells look more atypical under the microscope than the usual case of LCIS. Necrosis means that some of the LCIS cells are dead.
Is the pleomorphic lobular carcinoma er or PR negative?
The aggressive nature of the pleomorphic variant of invasive lobular carcinoma (ILC) and poorer outcomes are related to the high histologic grade of this variant, rather than the pleomorphic designation itself. While these tumors may be ER and PR negative in approximately 5 – 10% of cases, the majority are hormone receptor positive.
When was pleomorphic lobular carcinoma ( plc ) first described?
Pleomorphic lobular carcinoma (PLC) was first described by Dixon et al 1 (1982) and Page 2 (1987) as a variant of invasive lobular carcinoma, characterized by a diffuse spreading pattern similar to classical invasive lobular carcinoma (ILC) but without its typical cytologic features.
How many epithelial breast malignancies are pleomorphic?
It accounts for approximately 1% of all epithelial breast malignancies. In addition to its pleomorphism, it is characterized by aggressive behavior and shortened patient survival.