What is glaucomatous optic neuropathy?
What is glaucomatous optic neuropathy?
Glaucomatous optic neuropathy (GON) refers to excavation (depression) of the physiologic cup at the lamina cribrosa associated with chronic degeneration of the neuroretinal rim and subsequent loss of RGCs (visible as nerve fiber layer defects). From: Ocular Disease, 2010.
What is the present pathogenetic concept of glaucomatous optic neuropathy?
Glaucomatous optic neuropathy implies loss of neural tissue, activation of glial cells, tissue remodeling, and change of blood flow. The blood flow reduction is not only secondary but has a primary component. Activation of astrocytes leads to an altered microenvironment.
What is glaucomatous optic disc?
In glaucoma, the optic nerve gets damaged. There are many blood vessels that emerge from the optic disc to the retina. Glaucoma causes loss of the neural reddish tissue and there is progressive cupping of the optic disc – enlargement of the whitish central part.
What does glaucomatous mean?
Medical Definition of glaucomatous : of, relating to, or affected with glaucoma.
What is glaucomatous optic atrophy bilateral?
Optic atrophy is a condition that affects the optic nerve, which carries impulses from the eye to the brain. (Atrophy means to waste away or deteriorate.) There is no effective treatment for this condition.
What causes glaucomatous cupping?
In people with glaucoma damage, because of increased pressure in the eye and/or loss of blood flow to the optic nerve, these nerve fibers begin to die. This causes the cup to become larger in comparison to the optic disc, since the support structure is not there.
What causes bilateral optic neuropathy?
Optic neuropathy can be caused by demyelination, inflammation, ischemia, infiltration, compression, and hereditary and toxic/nutritional causes. Careful clinical evaluation is essential to rule in the diagnosis of optic neuropathy.
What is optic neuropathy symptoms?
Optic neuritis occurs when swelling (inflammation) damages the optic nerve — a bundle of nerve fibers that transmits visual information from your eye to your brain. Common symptoms of optic neuritis include pain with eye movement and temporary vision loss in one eye.
What is glaucomatous optic neuropathy ( Gon )?
Glaucomatous optic neuropathy (GON) is the pathohistological feature of glaucoma in the optic nerve. The pathogenesis of GON has been hypothesized, to either originate from compromised mechanical conditions at the lamina cribrosa or as associated with pathological vascular involvement.
Which is the best description of normal tension glaucoma?
Normal-tension glaucoma (NTG) is as an optic neuropathy characterized by optic disc excavation and corresponding visual field loss in the setting of an open anterior chamber angle and statistically normal IOP.
What kind of neuropathy is angle closure glaucoma?
Angle-closure glaucoma is glaucomatous optic neuropathy secondary to ocular hypertension caused by closure of the drainage angle. The angle closure could be primary, or secondary to other pathological processes such as in phacomorphic glaucoma.
How does optic nerve degeneration differ from glaucoma?
The compartmentalized degeneration of RGCs also occurs in models of optic nerve trauma, such as optic nerve crush, and while optic nerve deterioration varies from glaucoma and instead occurs by Wallerian degeneration, 69 axonal damage also precedes RGC loss, and RGC somas can be protected from crush by genetic deletion of BAX.18