What is Subepithelial deposit?
What is Subepithelial deposit?
Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and are a key diagnostic finding in IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without a precise clinical history.
What are mesangial deposits?
Mesangial deposits are granular and they can be found in IgA, IgM, and C1q nephropathies, in C3 mesangial GN, lupus nephritis class II, resolving postinfectious GN, and others. Figure 21. IgA Positivity in mesangial areas in a case of IgA nephropathy. See that capillary walls are not marked by the immunostaining.
Where are the locations of Subepithelial autoimmune deposits?
Subepithelial deposits located at the base of the podocyte foot processes outside the GBM are found in class V disease. In this type of disease, complement-mediated injury of podocytes induces them to lay down excessive matrix material that alters the structure of the basement membrane, leading to proteinuria.
What is Endocapillary proliferation?
Endocapillary proliferation (EP) is a common pathological finding in proliferative glomerulonephritis (GN). Its appearance indicates the presence of active lesions of GN. In this study, we reinvestigated the pathological features of EP.
What is mesangial Hypercellularity?
Abstract. Diffuse mesangial hypercellularity (DMH) is a rare primary mesangial proliferative glomerulonephritis associated with idiopathic nephrotic syndrome (INS).
What is an immune complex mediated disease?
Immune-complex deposition and Fcγ receptor (FcγR)-mediated activation of inflammatory responses by such immune complexes is a central pathogenic process in a variety of autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and vasculitis.
What is Extracapillary proliferation?
The term “extracapillary proliferation” is used to designate the cellular and/or fibrous proliferation that occupies the Bowman’s space, arising from its capsule. Extracapillary indicate that proliferation occur outside of capillary tuft.
What is mild mesangial Hypercellularity?
Diagnosis: Minimal change disease, hypercellular variant Diffuse mesangial hypercellularity is a well described microscopic change in some cases of idiopathic nephrotic syndrome. This histopathological pattern is thought to account for 2–10% of all patients with nephrotic syndrome.
Where are the subendothelial immunocomplex deposits located?
Subendothelial immunocomplex deposits – the band of electron-dense material extends around the glomerular basement membrane and hugs the interface of the membrane with the capillary lumen. The immune deposits will be beneath the nucleus of the endothelial cell (it gets through the fenestra but thats as far as it can get.)
Where are subepithelial deposits found in Class V disease?
These have access to the vascular space and can therefore mediate recruitment of inflammatory cells and subsequent endothelial damage. Subepithelial deposits located at the base of the podocyte foot processes outside the GBM are found in class V disease.
Is the subendothelial space filled with granular substances?
The subendothelial space (SES) appeared widened and filled with massive amount of granular substances in the OVX and OVX+ST groups as demonstrated by the distantly placed IEL (Figures 2 (b) and 2 (c)).
What causes the destruction of the subendothelial space?
The vasculitis involves destruction of small to medium-sized arteries that contain an inflammatory infiltrate within the vessel wall and subendothelial space, leading to destruction of the elastic lamina (figure 1).