What is the pathogenesis of DIC?
What is the pathogenesis of DIC?
Disseminated intravascular coagulation (DIC) is an acquired clinicobiological syndrome characterized by widespread activation of coagulation leading to fibrin deposition in the vasculature, organ dysfunction, consumption of clotting factors and platelets, and life-threatening hemorrhage.
What happen in case of DIC?
In some cases of DIC, small blood clots form in the blood vessels. Some of these clots can clog the vessels and cut off the normal blood supply to organs such as the liver, brain, or kidneys. Lack of blood flow can damage and cause major injury to the organs.
What is the mechanism of DIC?
Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation, which results in generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction syndrome (MODS).
What is the pathologic mechanism that triggers DIC?
Thus, major mechanisms for triggering DIC include release of tissue factor or thrombo-plastic substances into the circulation (activation of extrinsic pathway of coagulation), injury to endothelial cells exposing subendothelial collagen (activation of intrinsic and extrinsic pathways of coagulation), systemic …
How fast does DIC occur?
DIC may develop quickly over hours or days, or more slowly. Signs and symptoms may include bleeding, bruising, low blood pressure, shortness of breath, or confusion. Complications can be life-threatening and include bleeding or multiple organ failure.
Why is heparin given in DIC?
Heparin, as an anticoagulant, which, not only inhibits the activation of the coagulation system, but is also an anti-inflammatory and immunomodulatory agent, has been widely used during DIC treatment and in the prevention and treatment of thrombotic diseases.
What is included in DIC panel?
There is no single laboratory test that can establish or rule out a diagnosis of DIC. In clinical practice, a DIC panel typically consists of a platelet count, a fibrinogen level, a prothrombin and a partial thromboplastin time, and a measurement of D-dimer (or FDP) level.
What is the treatment for a DIC?
There is no specific treatment for DIC. The goal is to determine and treat the underlying cause of DIC. Supportive treatments may include: Plasma transfusions to replace blood clotting factors if a large amount of bleeding is occurring.
What is DIC mortality rate?
Prognosis varies depending on the underlying disorder, and the extent of the intravascular thrombosis (clotting). The prognosis for those with DIC, regardless of cause, is often grim: Between 20% and 50% of patients will die.
What is DIC condition?
ANSWER. Disseminated intravascular coagulation (DIC) is a condition that causes tiny blood clots and areas of bleeding throughout the body simultaneously; severe infections, surgery, or complications of pregnancy are conditions that can lead to DIC.