What is Trovan used for?
What is Trovan used for?
The TROVAN/ZITHROMAX Compliance Pak refers to a specific dual treatment for uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae and non-gonoccocal urethritis/cervicitis caused by Chlamydia trachomatis.
Why was Trovan taken off the market?
Pfizer withdrew Trovan from Markets worldwide in 2001 because of the risk of fatal liver failure.
Is Trovan safe?
Trovan® HAS BEEN ASSOCIATED WITH SERIOUS LIVER INJURY LEADING TO LIVER TRANSPLANTATION AND/OR DEATH. Trovan-ASSOCIATED LIVER INJURY HAS BEEN REPORTED WITH BOTH SHORT-TERM AND LONG-TERM DRUG EXPOSURE. Trovan USE EXCEEDING 2 WEEKS IN DURATION IS ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF SERIOUS LIVER INJURY.
Who made Trovan?
A secret Nigerian government report concluded that the drug manufacturer Pfizer undertook an “illegal trial of an unregistered drug” when the company enrolled nearly 100 Nigerian children with meningitis in a trial testing its antibiotic trovafloxacin (Trovan) against ceftriaxone during a 1996 meningitis epidemic.
What do fluoroquinolones treat?
The fluoroquinolones are indicated for treatment of several bacterial infections, including bacterial bronchitis, pneumonia, sinusitis, urinary tract infections, septicemia and intraabdominal infections, joint and bone infections, soft tissue and skin infections, typhoid fever, anthrax, bacterial gastroenteritis.
What does hepatotoxicity mean?
Toxic liver disease is damage to your liver. It’s also called hepatotoxicity or toxic hepatitis. It can cause serious symptoms or liver damage if you don’t get help. Medications, herbal supplements, chemicals, solvents, and alcohol are all possible causes of hepatotoxicity.
Is norfloxacin an antibiotic?
Norfloxacin is used to treat a variety of bacterial infections. This medication belongs to a class of drugs known as quinolone antibiotics. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
What Pfizer did in Nigeria?
US-based pharmaceutical giant Pfizer has made the first compensation payment to Nigerian families affected by a controversial drug trial 15 years ago. It paid $175,000 (£108,000) each to four families in the first of a series of payments it is expected to make.
What are the side effects of Trovan tablets?
(SEE WARNINGS .) Trovan is available as Trovan Tablets (trovafloxacin mesylate) for oral administration and as Trovan I.V. (alatrofloxacin mesylate injection), a prodrug of trovafloxacin, for intravenous administration. Trovan Tablets contain trovafloxacin mesylate, a synthetic broad-spectrum antibacterial agent for oral administration.
What are the pharmacokinetics of Trovan 100 mg?
The mean pharmacokinetic parameters (±SD) of trovafloxacin after single and multiple 100 mg and 200 mg oral doses and 1 hour intravenous infusions of alatrofloxacin in doses of 200 and 300 mg (trovafloxacin equivalents) appear in the chart below.
Why was Trovan withdrawn from the market in 2001?
Summary. Trovafloxacin mesylate (Trovan) is a medication prescribed to treat a variety of infections. Trovan was withdrawn from the Markets worldwide in 2001 because of the risk of liver failure in patients taking Trovan.
When to use Trovan instead of Alatrofloxacin?
Trovan SHOULD NOT BE USED WHEN SAFER, ALTERNATIVE ANTIMICROBIAL THERAPY WILL BE EFFECTIVE. (SEE WARNINGS .) Trovan is available as Trovan Tablets (trovafloxacin mesylate) for oral administration and as Trovan I.V. (alatrofloxacin mesylate injection), a prodrug of trovafloxacin, for intravenous administration.