Which isomer of Hexestrol is active?
Which isomer of Hexestrol is active?
Meta-hexestrol is also active on the hormone-independent human MDA-MB 231 breast cancer cell line (IC50 2.5 × 10−6 M). Its antiestrogenicity is comparable to nafoxidine (Hartmann et al., 1980; Kranzfelder et al., 1982). The tetramethyl-1,2-diphenylethanes (106,107) exhibited strongest antiestrogenic activity.
How is the synthesis of dibenzalacetone carried out?
Synthesis of Dibenzalacetone by Aldol Condensation. 1. To carry out a mixed aldol condensation reaction. 2. To study the mechanism of aldol condensation reaction. The reaction of an aldehyde with a ketone employing sodium hydroxide as the base is an example of a mixed aldol condensation reaction, the Claisen-Schmidt reaction.
How is aldol condensation used to make dibenzalacetone?
Condensation is a process which joins two or more molecules usually with the loss of a small molecule such as water or an alcohol. Aldol condensation (Claisen-Schmidt reaction) definitely is a process which join two carbonyl groups with a loss of water molecule in order to form β-hydroxyketone.
How to recrystallize dibenzalacetone as a solid?
Dibenzalacetone will crash out of the solution as a solid during the course of the reaction. Collect this solid via Hirsch filtration and wash it several times with small portions of cold water. Allow the solid to air dry by continuing to apply the vacuum for 2-3 min. Recrystallize the solid by dissolving in 2 mL of hot ethanol.
What is the molar mass of dibenzalacetone?
H3C C CH3 O 1 Acetone molar mass: 58 g/mol density: 0.79g/mL limiting reagent + 12 C H O Benzaldehyde molar mass: 106 g/mol density: 1.04 g/mL an excess will be used NaOH, H2O, CH3CH2OH CC O C H H H H original acetone carbons Dibenzalacetone molar mass: 234 g/mol melting point: somewhere between 80 and 120ºC H3C C C H2 O H OH H3C C CH2