Why is nimesulide banned?
Why is nimesulide banned?
Nimesulide must be withdrawn worldwide due to serious liver damage. Nimesulide exposes patients to fatal liver damage. When a non-steroidal anti-inflammatory drug is needed, it is better to use one with a favourable benefit-harm balance such as ibuprofen. EU authorities fail to protect consumers.
What is nimesulide tablets used for?
Nimesulide is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed. This drug belongs to the NSAID class (Non-steroidal anti-inflammatory drug).
Is nimesulide good for headache?
Nimesulide treatment brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache and produced a rapid lowering in body temperature. The recovery was more rapid and significant in patients with Nimesulide than in those with Benzydamine.
What is the action of nimesulide?
Nimesulide only weakly inhibits prostaglandin synthesis and appears to exert its effects through various mechanisms. It inhibits the release of oxidants from activated neutrophils and has a scavenging effect on hypochlorous acid without affecting neutrophil function.
Is nimesulide stronger than ibuprofen?
However, the results suggest that the analgesic effect of nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion) than that of ibuprofen. Both study drugs were well tolerated.
Is nimesulide still banned?
The government has banned the paediatric use of the common fever and pain drug nimesulide for its adverse effects on the liver, in a much- delayed move. The decision was taken by the Union health ministry after experts on the Drug Technical Advisory Board recommended banning the drug along with five others.
What are side effects of nimesulide?
Nimesulide is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
How quickly does nimesulide work?
Nimesulide has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.
Which is better nimesulide or paracetamol?
Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be at least as effective as paracetamol in terms of antipyretic and anti-inflammatory activity in children with inflammation of the upper respiratory tract and fever.
How much nimesulide is safe?
Current indications vary by country, but are generally limited to mild-to-moderate acute pain for which the recommended dose in adults is 100 mg twice daily for no more than 15 days. Chronic therapy is not generally recommended, and nimesulide is considered contraindicated in children.
Can I take nimesulide in empty stomach?
Always take Nimesulide together with food or immediately after a meal. Do not take it on an empty stomach.
Is it safe to take paracetamol with nimesulide?
Conclusions: Nimesulide and paracetamol combination offers no advantage over nimesulide alone or paracetamol alone, either in terms of degree of analgesia or onset of action. Therefore, our study supports the reports claiming irrationality of the fixed dose combination of nimesulide and paracetamol.