Can cimetidine cause warfarin toxicity?
Can cimetidine cause warfarin toxicity?
Cimetidine, the first marketed histamine2-receptor antagonist, has been shown to decrease the clearance of warfarin consistently through inhibition of cytochrome P-450 metabolism.
Does cimetidine increase INR?
Adverse Effects With any increase in thyroid function, there is potential for an increase in the INR of a patient taking warfarin due to increased catabolism of vitamin K-dependent clotting factors. [13][14] Cimetidine may increase the INR by inhibiting the metabolism of R-warfarin.
What drugs do cimetidine interact with?
Some products that may interact with this drug include: cisapride, dofetilide, epirubicin, ticlopidine, artemether, clopidogrel, lumefantrine, metformin, moclobemide, moricizine, quinidine, silver sulfadiazine.
Does cimetidine interact with other drugs?
After five years’ extensive use of cimetidine, drug interactions have emerged as one of its major adverse effects. Clinically important interactions with warfarin, phenytoin, diazepam, chlormethiazole, propranolol, lidocaine, and a number of other drugs have been reported.
Why do you take warfarin at 6pm?
In order to shorten the response time for making a dosing change, patients are traditionally advised to have their INR test in the morning and to take their warfarin in the evening (so that the INR test result will be back in time to change that day’s warfarin dose if needed).
Can warfarin cause eye problems?
Warfarin is the most commonly used drug for outpatient anticoagulation therapy and its main side-effect is bleeding; theoretically, this can occur in all organs, including the eye. Ocular bleeding can occur as subconjunctival, vitreal, retinal or choroidal haemorrhages; bloody tears have been also reported [3].
What should you not take with warfarin?
Common drugs that can interact with warfarin include:
- Aspirin or aspirin-containing products.
- Acetaminophen (Tylenol, others) or acetaminophen-containing products.
- Antacids or laxatives.
- Many antibiotics.
- Antifungal medications, such as fluconazole (Diflucan)
- Cold or allergy medicines.
Why is cimetidine banned?
The FDA said the medicines may contain “unacceptable” amounts of N-Nitrosodimethylamine (NDMA), a substance the World Health Organization has classified as a “probable human carcinogen.”
What can you not take with cimetidine?
Ask a doctor or pharmacist before using cimetidine with any other medications, especially:
- ketoconazole;
- phenytoin;
- theophylline;
- an antidepressant; or.
- a blood thinner–warfarin, Coumadin, Jantoven;
- heart or blood pressure medicine–nifedipine, propranolol; or.
- a sedative–chlordiazepoxide, diazepam.
Why is warfarin being discontinued?
The most commonly reported reasons for warfarin discontinuation were physician preference (47.7%), patient refusal/preference (21.1%), bleeding event (20.2%), frequent falls/frailty (10.8%), high bleeding risk (9.8%), and patient inability to adhere to/monitor therapy (4.7%).
How long can you stay on warfarin?
If you take warfarin to reduce your risk of having a blood clot in future or because you keep getting blood clots, it’s likely your treatment will be for longer than 6 months, maybe even for the rest of your life.
What vitamins should not be taken with warfarin?
Common supplements that can interact with warfarin include:
- Coenzyme Q10 (ubiquinone)
- Dong quai.
- Garlic.
- Ginkgo biloba.
- Ginseng.
- Green tea.
- St. John’s wort.
- Vitamin E.
What drugs interact with cimetidine?
Atazanavir ( Reyataz ®)
Does caffeine interact with warfarin?
While there are no known interactions between warfarin and caffeine, this does not necessarily mean that none exist. It is generally considered safe to consume caffeine while on warfarin, but always contact your doctor if you experience any unusual side effects.
Does rosuvastatin interact with warfarin?
Rosuvastatin – warfarin drug interaction . AstraZeneca have done at least two clinical studies on the co-administration of rosuvastatin and warfarin, and presumably the results of these studies provide the basis for the suggestion by the British National Formulary that there might be an interaction between rosuvastatin and warfarin.
What drugs affect INR?
Medications or substances that increase INR and risk of bleeding include: Antiarrhythmic medications: amiodarone, propafenone. Antibiotics: azithromycin ( Zmax , Zithromax), cefazolin ( Ancef , Kefzol), erythromycin (E-mycin, Ery-Tab, Eryc , E.E.S., Erythrocin), aspirin. Alcohol in beverages or cough medicines.