Why does hyperthyroidism occur in molar pregnancy?
Why does hyperthyroidism occur in molar pregnancy?
Molecular variants of hCG found in molar pregnancies have increased thyrotropic potency (7). When gestational trophoblastic disease causes a significant rise in hCG levels, it may induce hyperthyroidism that requires treatment. As expected, thyrotoxicosis resolves with treatment of GTD and normalization of hCG levels.
Can pregnancy cause a thyroid storm?
Some pregnant women have a severe life-threatening form of hyperthyroidism called thyroid storm. This is a condition in which there are very high levels of thyroid hormone. It can cause high fever, dehydration, diarrhea, fast and irregular heartbeat, shock, and even death, if not treated.
Which finding is associated with thyroid storm?
People with thyroid storm generally exhibit an increased heart rate, as well as a high top blood pressure number (systolic blood pressure). A doctor will measure your thyroid hormone levels with a blood test. Thyroid stimulating hormone (TSH) levels tend to be low in hyperthyroidism and thyroid storm.
Are you considered high risk after molar pregnancy?
The risk of recurrence is low, but higher than the risk for women with no previous history of molar pregnancy. During any subsequent pregnancies, your care provider may do early ultrasounds to monitor your condition and offer reassurance of normal development.
What is a twin molar pregnancy?
Twin molar pregnancy is a rare obstetric event, characterized by the coexistence of a hydatidiform mole and a potentially viable fetus with a normal placenta, associated with several pregnancy complications, such as spontaneous abortions, intrauterine deaths, preeclampsia, and hyperthyroidism, potentially leading to an …
Why do hydatidiform moles cause hyperthyroidism?
Gestational trophoblastic disease (GTD) which includes hydatidiform mole, invasive mole, placental site trophoblastic tumor, and choriocarcinoma is a rare cause of hyperthyroidism due to excess production of placental human chorionic gonadotrophin hormone (hCG) by tumor cells.
What is effect on baby if mother is hyperthyroidism?
Uncontrolled hyperthyroidism has many effects. It may lead to preterm birth (before 37 weeks of pregnancy) and low birth weight for the baby. Some studies have shown an increase in pregnancy-induced hypertension (high blood pressure of pregnancy) in women with hyperthyroidism.
What is Thyroid storm?
Thyroid storm is a very rare, but life-threatening condition of the thyroid gland that develops in cases of untreated thyrotoxicosis (hyperthyroidism, or overactive thyroid). The thyroid gland is located in the neck, just above where your collarbones meet in the middle.
What is the best treatment for a thyroid storm?
When treating thyroid storm, one should consider the five ‘Bs’: Block synthesis (i.e. antithyroid drugs); Block release (i.e. iodine); Block T4 into T3 conversion (i.e. high-dose propylthiouracil [PTU], propranolol, corticosteroid and, rarely, amiodarone); Beta-blocker; and Block enterohepatic circulation (i.e. …
What percent of molar pregnancies are cancerous?
Fewer than 15% of molar pregnancies become invasive and spread outside of the uterus. Choriocarcinoma. This is a cancerous tumor formed from trophoblast cells.
What is the main cause of molar pregnancy?
What causes a molar pregnancy? Molar pregnancies result when specific genetic errors occur during the fertilization of an egg by a sperm. In a healthy pregnancy, a placenta forms to nourish the growing embryo. With a molar pregnancy, instead of a placenta, a tumor forms inside the uterus.
How often does molar pregnancy-induced thyroid storm occur?
Background: Molar pregnancy is a rare form of pregnancy, affecting approximately 1 in 1000 pregnancies in the United States. Hyperthyroidism is a rare complication of molar pregnancy; thyroid storm occurs even less frequently.
Can a thyroid storm be induced by pregnancy?
Conclusions: Thyroid storm induced by gestational trophoblastic disease should be considered in any woman of childbearing age who presents with symptoms suggestive of hyperthyroidism. Copyright © 2010 Elsevier Inc. All rights reserved.
Which is a rare complication of molar pregnancy?
Background: Molar pregnancy is a rare form of pregnancy, affecting approximately 1 in 1000 pregnancies in the United States. Hyperthyroidism is a rare complication of molar pregnancy; thyroid storm occurs even less frequently. Objectives: To discuss a rare cause of thyroid storm in a woman of reproductive age.