Does L arginine help with cancer?
Does L arginine help with cancer?
A few trials of arginine supplementation have been conducted in cancer patients. Some show that arginine-enriched nutritional formulas taken around the time of surgery may improve wound healing, enhance immune status, and reduce length of hospital stay.
What is arginine Auxotrophy?
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis.
Is arginine bad for cancer?
Depriving cancer cells from arginine does not only have a cytotoxic effect but also induces cell cycle arrest in some types of cancer cells. Cell cycle analysis was done on the surviving population of ovarian and pancreatic cancer cells to examine the effect of arginine deprivation on the cell cycle.
What are the side effects of taking L-Arginine?
Oral use of L-arginine might cause:
- Nausea, abdominal pain and diarrhea.
- Bloating.
- Gout.
- Headache.
- Allergic response.
- Airway inflammation or worsening of asthma symptoms.
What is arginine metabolism?
Arginine has multiple metabolic fates and thus is one of the most versatile amino acids. Not only is it metabolically interconvertible with the amino acids proline and glutamate, but it also serves as a precursor for synthesis of protein, nitric oxide, creatine, polyamines, agmatine, and urea.
How is pegylated arginine used to treat pancreatic cancer?
We explored the therapeutic potential of depleting exogenous arginine via pegylated arginine deiminase (ADI-PEG20) treatment as an adjunct to radiotherapy. We evaluated the efficacy of treatment of human pancreatic cancer cell lines and xenografts with ADI-PEG20 and radiation via clonogenic assays and tumor growth delay experiments.
Can a tumor not synthesize arginine independently?
In recent years, researchers found that certain tumors were not capable to synthesize arginine independently, which seize a good opportunity to win the battle with cancer [2]. In fact, there are several amino acids with dysfunctional metabolism in cancer cells.
How is arginine depletion used in cancer therapy?
Depletion of this amino acid by arginine depletor is generally well tolerated and has become a targeted therapy for arginine auxotrophic cancers. However, the modulatory eff ;ect of arginine on cancer cells is very complicated and still controversial.
How does arginine affect the metabolism of cancer cells?
Certain cancer cells with nutrient auxotrophy and have a much higher nutrient demand compared with normal human cells. Arginine as a versatile amino acid, has multiple biological functions in metabolic and signaling pathways.