Is Pyrazine basic?
Is Pyrazine basic?
Pyrazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods.
Which heteroatom is present in Pyrazine?
Pyrazine, any of a class of organic compounds of the heterocyclic series characterized by a ring structure containing four atoms of carbon and two of nitrogen.
How many aromatic compounds are possible for molecule having molecular formula c4h4n2?
Pyrazines are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms….Structure for FDB012468 (Pyrazine)
| Property | Value | Source |
|---|---|---|
| Water Solubility | 534 g/L | ALOGPS |
| logP | -0.29 | ALOGPS |
| logP | -0.46 | ChemAxon |
| logS | 0.82 | ALOGPS |
Is pyrazine a Diazine?
Pyrazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2….CHEBI:30953 – pyrazine.
| ChEBI Name | pyrazine |
|---|---|
| Definition | A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms. |
Is pyridazine basic?
Pyridazines (also known as 1,2-diazine, orthodiazine, or oizine) are six-membered heterocylic aromatic organic compounds with two nitrogen atoms which are adjacent to each other. The diazines are essentially mono-basic substances and weaker bases than pyridine.
Is Pyrazine a functional group?
Pyrazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2. It is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods.
Is piperidine acidic or basic?
Piperidine is the most basic (conjugate acid pKa = 11.2).
Where can you find pyrazine derivatives in food?
Thirty-four of the 41 pyrazine derivatives in this group of flavouring agents are naturally occurring components of food. Members of this group have been detected in asparagus, potato, kohlrabi, and wheaten bread (Maarse et al., 1996).
How much pyrazine is produced in a year?
The total annual production of the 41 pyrazine derivatives in this group is approximately 2700 kg in Europe (International Organization of the Flavor Industry, 1995) and 2100 kg in the USA (Lucas et al., 1999).
What should the intestinal pH be for pyrazine?
Pyrazine is a weak base (pK b = 13.4). The absorption of weak amine bases such as pyrazine derivatives is optimal at intestinal pH (5–7) (Schranker et al., 1957; Hogben et al., 1959).
Which is better a pyrazine derivative or azd1092?
Profiling of the pyrazine derivative (45) in rat and dog pharmacokinetic studies revealed that the compound had excellent oral absorption (100% bioavailability in both species) and overall physicochemical and pharmacokinetic properties clearly superior to those of AZD1092 ( 30 ). Comparative data are shown in Table 1.15. Table 1.15.
