What are two examples of microtubule-associated proteins?
What are two examples of microtubule-associated proteins?
These include STOP (also known as MAP6), and ensconsin (also known as MAP7). In addition, plus end tracking proteins, which bind to the very tip of growing microtubules, have also been identified. These include EB1, EB2, EB3, p150Glued, Dynamitin, Lis1, CLIP170, CLIP115, CLASP1, and CLASP2.
What causes hyperphosphorylation of tau protein?
Proposed mechanism of neurofibrillary degeneration and targets for therapeutic interventions. Multiple etiological factors cause abnormal hyperphosphorylation of tau via various pathways, including Aβ, dysregulation of phosphorylation/dephosphorylation, and impaired brain glucose metabolism.
What are microtubule-associated proteins and how are they important?
Axonal microtubules have two essential roles: providing the track for organelle transport and forming the cytoskeletal framework to maintain axonal morphology. Microtubule-associated proteins (MAPs) are essential for the formation of cytoskeletal architecture.
What is the function of microtubule-associated proteins?
Microtubule-associated proteins (MAPs) regulate assembly and stability of microtubules. Microtubules constitute a major part of the cytoskeleton and are important in cytoskeletal rearrangements during neuronal growth, axon guidance, and synapse formation.
What pathways produces microtubule proteins in cells?
The ras-related nuclear protein (Ran) pathway forms gradients around chromosomes in mitosis that are believed to control the spatial regulation of microtubule nucleation and dynamics (12–14) and has been hypothesized to contribute to spindle length (15, 16) and the kinetics of chromosome capture (17).
What is the function of tau proteins?
Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal physiological conditions. However, in certain pathological situations, tau protein may undergo modifications, mainly through phosphorylation, that can result in the generation of aberrant aggregates that are toxic to neurons.
