What is the half life of docetaxel?
What is the half life of docetaxel?
After short intravenous infusions of 70-115 mg/m2 every 3 weeks, a three phase disposition profile was observed with a terminal half-life of 12 hours and a plasma clearance of 21 l/hr/m2.
How effective is docetaxel for breast cancer?
Docetaxel (Taxotere) is among the most active agents for metastatic breastcancer. Initial phase II studies of docetaxel administered at 100 mg/m² showedresponse rates of 53% to 68% in patients previously treated withchemotherapy. [2-6] A multicenter phase II study of docetaxel at 75 mg/m² showeda response rate of 52%.
What is docetaxel in breast cancer?
Docetaxel (Taxotere), a cytotoxic taxane, is an antimicrotubule agent effective in the treatment of patients with breast cancer. The clinical profile of docetaxel as an effective cytotoxic agent in the treatment of metastatic breast cancer is well established.
Is Taxotere and tamoxifen the same?
Docetaxel and Tamoxifen are anti-cancer drugs that have shown impressive treatment among the female breast cancer patients population. Docetaxel, which trade name is Taxotere, is a chemotherapy drug that has been used for different stages of breast cancers – early, advanced stage, and metastatic breast cancers.
Is docetaxel a strong chemo?
Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).
How bad is docetaxel?
Docetaxel may cause severe lack or loss of strength, which can last a few days up to several weeks. Tell your doctor if you unusual tiredness or weakness. This medicine contains alcohol and may cause some people to become drowsy, dizzy, or less alert than they are normally.
How long can you stay on docetaxel?
Effective birth control is necessary during treatment and for 6 months after treatment for women. Men who are treated with this medication should use effective birth control during and for 3 months after the last dose.
How many times can you have docetaxel?
How long will I have docetaxel for? For primary breast cancer three to six treatment cycles are usually given. For locally advanced and secondary breast cancer the number of cycles will vary depending on the individual.
What kind of drug is docetaxel for cancer?
Docetaxel. Drug type: Docetaxel is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as a “plant alkaloid,” a “taxane” and an “antimicrotubule agent.” (For more detail, see “How this drug works” section below).
Is it bad to take docetaxel with alcohol?
Docetaxel contains alcohol. Using other drugs that can make you sleepy can worsen the feeling of being drunk. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect docetaxel, including prescription and over-the-counter medicines]
When to use docetaxel in combination with doxorubicin?
Docetaxel Injection is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Docetaxel Injection in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer.
When to go to the ER for docetaxel?
Get emergency medical help if you have hives, a red skin rash, trouble breathing, or swelling of your face, lips, tongue, or throat. You may have swelling in your intestines, which could cause death quickly. Call your doctor right away if you have stomach pain or tenderness, diarrhea, or fever.