What is the half-life of tamoxifen in mice?
What is the half-life of tamoxifen in mice?
Table 1
| Dose (mg/kg) | Subcutaneous | |
|---|---|---|
| 4 | 20 | |
| Cmax (ng/ml)* | 20.5 ± 4.6 | 49.4 ± 8.6 |
| Tmax (h) | 2.0 | 4.0 |
| Half-life (h) | 7.7 | 11.2 |
Is tamoxifen toxic to mice?
Tamoxifen treatments have been widely reported to produce toxicity or death in mice. This can include stomach, intestinal and liver cellular abnormalities.
How long does it take for tamoxifen to leave your system?
How long does tamoxifen stay in your system? Tamoxifen stays active in the body for about 1 to 2 weeks after your last dose but can take about 3 months to completely leave your system.
Why is tamoxifen used in mice?
However, in laboratory mice, tamoxifen sustains a completely different function: it is used in genetic engineering to activate genes through a cascade of events.
What is a contraindication for tamoxifen?
For patients taking tamoxifen for breast cancer risk reduction at high risk for breast cancer or with ductal carcinoma in situ, it should be avoided if the patient has a history of deep vein thrombosis (DVT) or pulmonary embolism (PE).
Is tamoxifen stable at room temperature?
Tamoxifen can be stored at room temperature for up to a week.
How do you make tamoxifen solution?
Procedure: Dissolve tamoxifen (Sigma‐Aldrich) in corn oil at a concentration of 20 mg/ml by shaking overnight at 37°C. Tamoxifen is light sensitive, and should be made and stored in a light‐ blocking vessel (amber, or foil wrapped). After tamoxifen is in solution, store at 4°C for the duration of injections.
What do I need to know about tamoxifen?
Tamoxifen can: reduce the risk of breast cancer coming back by 40% to 50% in postmenopausal women and by 30% to 50% in premenopausal women. reduce the risk of a new cancer developing in the other breast by about 50% shrink large, hormone-receptor-positive breast cancers before surgery.
Who should not take tamoxifen?
Most experts agree that tamoxifen and raloxifene should not be used to reduce breast cancer risk in women who: Have a higher risk of serious blood clots* Are pregnant or planning to become pregnant. Are breastfeeding.
What not eat or drink when taking tamoxifen?
You certainly don’t want to take a medication to reduce breast cancer risk, only to eat or drink something that renders the tamoxifen less effective. The foods of most concern for women taking tamoxifen are grapefruit and tangerines. Grapefruit is well-known to interfere with numerous medications.
What to expect after tamoxifen?
On the low end of the scale, tamoxifen can cause nausea, hair loss, vomiting, bone pain, and weight gain. More seriously, it can contribute to the formation of blood clots and cataracts.
How effective is tamoxifen?
It’s only effective for some types of cancer. Studies have shown that tamoxifen can reduce the risk of cancer in high-risk women by more than 30%. But because the drug affects estrogen receptors in the body, it only works against cancers that are estrogen-receptor-positive or progesterone-receptor positive.
What are side effects of tamoxifen for breast cancer?
Tamoxifen is typically taken daily by mouth for five years for breast cancer. Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. Common side effects include irregular periods, weight loss, and hot flashes.
Is tamoxifen right for me?
For many men and women, choosing Tamoxifen may be the right choice for them. For others the side effects are very real, and the risk is too high- namely the risk of developing uterine cancer, blood clots, muscle pain, mental fogginess and cataracts.