What medications can cause myopathy?
What medications can cause myopathy?
Direct myotoxicity – Examples include alcohol, cocaine, glucocorticoids, lipid-lowering drugs, antimalarials (which are associated with vacuolar myopathies), colchicine (which is associated with vacuolar myopathies), and zidovudine (which causes a mitochondrial myopathy).
What can cause myopathy?
Myopathy develops as the result of either inherited (congenital or genetic) disorders or acquired conditions of the muscles. Most commonly, people develop acquired myopathy from muscle fatigue, electrolyte imbalance, or dehydration, resulting in stiffness or cramping.
Is drug-induced myopathy reversible?
Most drug-induced myopathies are reversible upon drug discontinuation if recognized early. They commonly include acute mild to severe myalgia and/or muscle weakness, sometimes accompanied by serum creatine kinase (CK) elevations.
What is drug-induced myopathy?
A drug-induced myopathy is defined as the subacute, and rarely acute, manifestation of myopathic symptoms, such as muscle weakness, fatigue, myalgia, creatine kinase (CK) elevation or myoglobinuria, that occur in patients without muscle disease when exposed to therapeutic doses of certain drugs.
How long does toxic myopathy last?
Manifestations of statin-associated toxic necrotizing myopathy resolve within 1 week to 3 months after stopping the statin. Persistent symptoms or creatine kinase level elevations thereafter should prompt consideration of immune-mediated necrotizing myopathy or other underlying disorders.
Can myopathy be treated?
Supportive and symptomatic treatment may be the only treatment available or necessary for some disorders. Treatment for other disorders may include drug therapy, such as immunosuppressives, physical therapy, bracing to support weakened muscles, and surgery. The prognosis for individuals with a myopathy varies.
What are the treatments for myopathy?
Certain types of myopathies can be treated with immune-suppressant agents and IVIG. Most myopathies require the use of supportive services, such as physical and occupational therapy, pulmonary medicine, cardiology, dietary management, and speech/swallowing therapists.
How does correcting the cause of myopathy help the symptoms?
When there is an identifiable cause, such as an endocrine problem, correcting the cause can help improve the symptoms of myopathy, or may at least help prevent it from worsening. Often, respiratory support is the key component in advanced myopathy, so that your breathing can be safely maintained. 1
What are some of the most common inherited myopathies?
Commonly inherited myopathies include: Mitochondrial myopathy : This is a disease caused by a defect in the energy-producing part of the cell, the mitochondria. There are several types of mitochondrial myopathy. While they can be caused by hereditary mutations (abnormalities in the genes) they can also occur without any family history. 1
What are the side effects of inflammatory myopathies?
Inflammation damages the muscle fibers, which causes weakness, and may affect the arteries and blood vessels that pass through muscle. Other symptoms include fatigue after walking or standing, frequent episodes of tripping or falling, and difficulty swallowing or breathing.
Are there any approved therapies for inflammatory myopathies?
Currently, there are no therapies approved by the U.S. Food and Drug Administration for diagnosing inflammatory myopathies. NIH-funded researchers are looking for better, less invasive ways of diagnosing these disorders.